Group publications on Enzyme Evolution project

Wouters MA, Liu K, Riek P, Husain A. A despecialization step underlying evolution of a family of serine proteases. Mol Cell 2003; 12:343-54  PubMed
How enzymes and other proteins have evolved is critical to understanding how they function and how they may be altered to advantage, to produce "designer" enzymes with new functions. In this paper, a Jurassic enzyme (over 170 million years old) is recreated and studied, revealing a major new understanding of how it evolved and functions.

Wouters MA, Husain A Changes in zinc ligation promote remodeling of the active site in the zinc hydrolase superfamily. Mol Biol 2001; 314: 1191-207  PubMed
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