Publications

2015
Haworth NL, Iismaa SE, Fan SW, Wouters MA Cross-Strand Disulfides in the non-hydrogen bonding site of antiparallel site β-sheet (aCSDs): poised for biological switching. RSC Advances 2015. (accepted 2/10/2015)  
Bouveret R, Waardenberg AJ, Schonrock N, Ramialison M, Doan T, de Jong D, Bondue A, Kaur G, Mohamed S, Fonoudi H, Chen C, Wouters MA, Bhattacharya S, Plachta N, Dunwoodie SL, Chapman G, Blanpain C, Harvey RP NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets. Elife   Open Access
Grover M, Ballouz S, Mohanasundaram K, George R, Sherman C, Crowley T, Wouters MA Identification of novel therapeutics for Coronary artery disease. BMC Medical Genomics 2015 7(Suppl 1):S8   Open Access
Mohanasundaram K, Haworth L, Grover M, Crowley T, Goscincski A, Wouters MA Potential role of glutathione in the evolution of thiol-based redox signaling sites in proteins. Frontiers in Pharmacology 2015.   Open Access
2014
Grover M, Ballouz S, Mohanasundaram K, George R, Sherman C, Crowley T, Wouters MA Identification of novel therapeutics for complex diseases from genome wide association data. BMC Medical Genomics 2014 7(Suppl 1):S8   Open Access
Ballouz S, Liu JY, Oti M, Gaeta B, Fatkin D, Bahlo M, Wouters MA Candidate disease gene prediction using Gentrepid: application to a genome-wide association study on coronary artery disease. Molecular Genetics & Genomic Medicine 2014 2, 44-47   Open Access
2013
Ballouz S, Liu JY, Oti M, Gaeta B, Fatkin D, Bahlo M, Wouters MA Gentrepid V2.0: a web server for candidate disease gene prediction. BMC Bioinformatics 2013 14, 249   Open Access
Haworth NL, Iismaa SE, Fan SW, Wouters MA Between-Strand Disulfides: Forbidden Disulfides Linking Adjacent β-Strands. RSC Advances 2013 3. 24680-24705   Open Access
2012
Mann S, Otway R, Guo G, Soka M, Karlsdotter L, Trivedi G, Ohanian M, Zodgekar P, Smith RA, Wouters MA, Subbiah R, Walker B, Kuchar D, Sanders P, Griffiths L, Vandenberg JI, Fatkin D Epistatic Effects of Potassium Channel Variation on Cardiac Repolarization and Atrial Fibrillation Risk. JACC 2012 59: 1017-25   Open Access
2011
Ballouz S, Liu JY, Oti M, Gaeta B, Fatkin D, Bahlo M, Wouters MA Analysis of genome-wide association study data using the protein knowledge base. BMC Genetics 2011 12:98   Open Access
Haworth NL, Iismaa S, Fan SW, Wouters MA Thiol-based redox signaling: Rust never sleeps. Int J Biochem Cell Biol 2011 43: 1079-85   Open Access
Chiu Joyce, Tactacan Carole, Tan Shi-Xiong, Lin Ruby, Wouters MA, Dawes IW Cell-cycle sensing of oxidative stress in S. cerevisiae by oxidation of a specific cysteine residue in Swi6p. Biol Chem. 2011 286:5204-14   Open Access
Sparrow DB, Sillence D, Wouters MA, Fatkin D, Turnpenny PD, Dunwoodie SL Two new missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis. Eur J Human Genet 2011 18:674-679   Open Access
2010
Wouters MA, Fan SW, Haworth NL Disulfides as redox switches: from molecular mechanisms to functional significances. Antioxid Redox Signal. 2010 Jan;12(1):53-91   Open Access
Sparrow DB, Sillence D, Wouters MA, Turnpenny PD, Dunwoodie SL. Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis. Eur J Hum Genet. 2010 Jun;18(6):674-9   Open Access
Haworth NL, Liu JY, Fan SW, Gready JE, Wouters MA Estimating Relative Disulfide Energies: An Accurate Ab Initio Potential Energy Surface. Aust J Chem. 2010;63(3):379-387  
2009
Teber ET, Liu JY, Ballouz S, Fatkin D and Wouters MA Comparison of automated candidate gene prediction systems using genes implicated in type 2 diabetes by genome-wide association studies. BMC Bioinformatics. 2009 Jan 30;10 Suppl 1:S69   PubMed  Open Access
Kurz M, Iturbe-Ormaeitxe I, Jarrott R, Shouldice SR, Wouters MA, Frei P, Glockshuber R, Oneill S, Heras B, Martin J STRUCTURAL AND FUNCTIONAL CHARACTERISATION OF THE OXIDOREDUCTASE alpha-DSBA1 FROM WOLBACHIA PIPIENTIS. Antioxid Redox Signal. 2009 Mar 5   Open Access
Fan SW, George RA, Haworth NL, Feng LL, Liu JY, Wouters MA Conformational changes in redox pairs of protein structures. Protein Sci 2009 Aug;18(8):1745-65   Open Access
2008
George RA, Smith TD, Callaghan S, Hardman L, Pierides C, Horaitis O, Wouters MA, Cotton RG Response to Stenson et al on the review of general mutation databases. J Med Genet. 2008 May;45(5):319-20.   Open Access
George RA, Smith TD, Callaghan S, Hardman L, Pierides C, Horaitis O, Wouters MA, Cotton RG General mutation databases: analysis and review. J Med Genet. 2008 Feb;45(2):65-70. Epub 2007 Sep 24. Review.   Open Access
Pang CN, Lin K, Wouters MA, Heringa J, George RA Identifying foldable regions in protein sequence from the hydrophobic signal. Nucleic Acids Res. 2008 Feb;36(2):578-88. Epub 2007 Dec 1.   PubMed  Open Access
2007
Wouters MA, George RA, Haworth NL "Forbidden" disulfides: their role as redox switches Curr Protein Pept Sci. 2007 Oct;8(5):484-95. Review. Open Access
Haworth NL, Gready JE, George RA, Wouters MA Evaluating the stability of disulfide bridges in proteins: a torsional potential energy surface for diethyl disulfide. Molecular Simulation. 2007 Vol 33:475-485 Open Access
2006
George RA, Liu JY, Feng LL, Bryson-Richardson RJ, Fatkin D and Wouters MA Analysis of protein sequence and interaction data for candidate disease gene prediction. Nucleic Acids Res. 2006;(34):e130. Epub 2006 Oct 4   Pubmed  Open Access
Haworth NL, Feng LL, Wouters MA. High torsional energy disulfides: relationship between cross-strand disulfides and right-handed. J Bioinform Comput Biol. 2006; 4:155-68.   Open Access
Sparrow DB, Chapman G, Wouters MA, Whittock NV, Ellard S, Fatkin D, Turnpenny PD, Kusumi K, Sillence D, Dunwoodie SL. Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Am J Hum Genet. 2006; 78: 28-37   PubMed
Begg GE, Carrington L, Stokes PH, Matthews JM, Wouters MA, Husain A, Lorand L, Iismaa SE, Graham RM Mechanism of allosteric regulation of transglutaminase 2 by GTP. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19683-8. Epub 2006 Dec 18.   PubMed  Open Access
2005
Chu CK, Feng LL, Wouters MA. Comparison of sequence and structure-based datasets for nonredundant structural data mining. Proteins. 2005; 60:577-83   PubMed
Wouters MA, Rigoutsos I, Chu CK, Feng LL, Sparrow DB, Dunwoodie SL. Evolution of distinct EGF domains with specific functions. Protein Sci 2005; 14:1091   PubMed
2004
Whittock NV, Sparrow DB, Wouters MA, Sillence D, Ellard S, Dunwoodie SL, Turnpenny PD. Mutated MESP2 causes spondylocostal dysostosis in humans. Am J Hum Genet 2004; 74:1249-54   PubMed
Wouters MA, Lau KK, Hogg PJ. Cross-strand disulphides in cell entry proteins: poised to act. Bioessays 2004; 26:73-9   Open Access
2003
Iismaa SE, Holman S, Wouters MA, Lorand L, Graham RM, Husain A. Evolutionary specialization of a tryptophan indole group for transition state stabilization by eukaryotic transglutaminases. Proc Natl Acad Sci USA 2003; 100:12636-41 http://www.pnas.org/PubMed Open Access
Wouters MA, Liu K, Riek P, Husain A. A despecialization step underlying evolution of a family of serine proteases. Mol Cell 2003; 12:343-54   PubMed   http://www.molecule.org/.
How enzymes and other proteins have evolved is critical to understanding how they function and how they may be altered to advantage, to produce "designer" enzymes with new functions. In this paper, a Jurassic enzyme (over 170 million years old) is recreated and studied, revealing a major new understanding of how it evolved and functions.
2001
Fernandez M, Liu X, Wouters MA, Heyberger S, Husain A Angiotensin I-converting enzyme transition state stabilization by HIS1089: evidence for a catalytic mechanism distinct from other gluzincin metalloproteinases. J Biol Chem 2001; 276: 4998-5004   Open Access
Liu X, Fernandez M, Wouters MA, Heyberger S, Husain A Arg(1098) is critical for the chloride dependence of human angiotensin I-converting enzyme C-domain catalytic activity. J Biol Chem 2001; 276: 33518-25   Open Access
Wouters MA, Husain A Changes in zinc ligation promote remodeling of the active site in the zinc hydrolase superfamily. Mol Biol 2001; 314: 1191-207   PubMed
1995
Wouters MA, Curmi PM An analysis of side chain interactions and pair correlations within antiparallel beta-sheets: the differences between backbone hydrogen-bonded and non-hydrogen-bonded residue pairs. Proteins 1995; 22:119-31   PubMed
© 2015 Merridee Wouters. | Website feedback | Last modified: 29 Jan 2016